Recent Publications from the Washington University Tuberous Sclerosis Center:

1. Rensing NR, Han L, Wong M.  Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex.  Epilepsia 2015; 56:1088-97. PMID: 26122303

2.  Zhang B, Zou J, Rensing NR, Yang M, Wong M. Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex.  Neurobiol Dis 2015; 80:70-79. PMID:26003087

3. Zhang B, Zou J, Han L, Rensing N, Wong M. Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex. Epilepsia 2016; 57:1317-1325.  PMID: 27263494

4. Jeong A, Wong M. Tuberous sclerosis as a model disease for developing new therapeutics for epilepsy. Expert Rev Neurotherap 2016: 16:437-447.  PMID: 26854692

5. Jeong A, Wong M. Systemic disease manifestations associated with epilepsy in tuberous sclerosis complex. Epilepsia 2016; 57:1443-1449. PMID: 27417921

6. Zou J, Zhang B, Gutmann DH, Wong M. Postnatal reduction of tuberous sclerosis complex-1 expression in astrocytes and neurons causes seizures in an age-dependent manner. Epilepsia 2017; 58:2053-2063. PMID:29023667

7. Jeong A, Nakagawa J, Wong M. Predictors of drug-resistant epilepsy in tuberous sclerosis complex. J Child Neurol 2017; 32:1092-1098. PMID: 29129154

8. Franz DN, Lawson JA, Yapici Z, Brandt C, Kohrmann MH, Wong M, Milh M, Vol M, Coello N, Cheung W, Grosch K, French JA. Everolimus dosing recommendations for tuberous sclerosis complex-assocated refractory seizures. Epilepsia 2018;59:1188-1197, PMID: 29727013

9. Krueger DA, Capal JK, Curatolo P, Devinsky O, Ess K, Tzadok M, Koenig MK, Naravanan V, Ramos F, Jozwiak S, de Vries P, Jansen AC, Wong M, Mowat D, Lawson J, Bruns S, Franz DN, TSCure Research Group. Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): multicenter clinical experience.  Eur J Paediatr Neurol 2018; Epub ahead of print.  PMID: 30005812

10. Zhang B, Zou J, Han L, Beeler B, Friedman JL, Griffin E, Piao Y-S, Rensing NR, Wong M. The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex. Epilepsia 2018; 59:1796-1806. PMID: 30079598