Recent Publications from the Washington University Tuberous Sclerosis Center:
1. Rensing NR, Han L, Wong M. Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex. Epilepsia 2015; 56:1088-97. PMID: 26122303
2. Zhang B, Zou J, Rensing NR, Yang M, Wong M. Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex. Neurobiol Dis 2015; 80:70-79. PMID:26003087
3. Zhang B, Zou J, Han L, Rensing N, Wong M. Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex. Epilepsia 2016; 57:1317-1325. PMID: 27263494
4. Jeong A, Wong M. Tuberous sclerosis as a model disease for developing new therapeutics for epilepsy. Expert Rev Neurotherap 2016: 16:437-447. PMID: 26854692
5. Jeong A, Wong M. Systemic disease manifestations associated with epilepsy in tuberous sclerosis complex. Epilepsia 2016; 57:1443-1449. PMID: 27417921
6. Zou J, Zhang B, Gutmann DH, Wong M. Postnatal reduction of tuberous sclerosis complex-1 expression in astrocytes and neurons causes seizures in an age-dependent manner. Epilepsia 2017; 58:2053-2063. PMID:29023667
7. Jeong A, Nakagawa J, Wong M. Predictors of drug-resistant epilepsy in tuberous sclerosis complex. J Child Neurol 2017; 32:1092-1098. PMID: 29129154
8. Franz DN, Lawson JA, Yapici Z, Brandt C, Kohrmann MH, Wong M, Milh M, Vol M, Coello N, Cheung W, Grosch K, French JA. Everolimus dosing recommendations for tuberous sclerosis complex-assocated refractory seizures. Epilepsia 2018;59:1188-1197, PMID: 29727013
9. Krueger DA, Capal JK, Curatolo P, Devinsky O, Ess K, Tzadok M, Koenig MK, Naravanan V, Ramos F, Jozwiak S, de Vries P, Jansen AC, Wong M, Mowat D, Lawson J, Bruns S, Franz DN, TSCure Research Group. Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): multicenter clinical experience. Eur J Paediatr Neurol 2018; Eur J Paediatr Neurol 2018;22:1066-1073. PMID: 30005812
10. Zhang B, Zou J, Han L, Beeler B, Friedman JL, Griffin E, Piao Y-S, Rensing NR, Wong M. The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex. Epilepsia 2018; 59:1796-1806. PMID: 30079598
11. Zhang B, Guo D, Han L, Rensing N, Satoh A, Wong M. Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex. Neurobiol Dis 2020 Feb;134:104615.. PMID 31605778.
12. Rensing N, Johnson KJ, Foutz TJ, Friedman JL, Galindo R, Wong M. Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex. Epilepsia 2020; 61:879-891. PMID: 32274803
13. Thiele EA, Bebin M, Bhathal H, Jansen FE, Kotulska K, Lawson JA, O’Callaghan FE, Wong M, Sahebkar F, Checketts D, Knappertz V. Add-on cannabidiol treatment for drug-resistant seizures in tuberous sclerosis complex: results of a randomized, placebo-controlled trial. JAMA Neurology 2020;e204607. PMID: 33346789
14. Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Epilepsy Res. 2022 Mar;181:106890. doi: 10.1016/j.eplepsyres.2022.106890. Epub 2022 Feb 18. PMID: 35219048; PMCID: PMC8930622.
15. Aum DJ, Reynolds RA, McEvoy SD, Wong M, Roland JL, Smyth MD. Laser interstitial thermal therapy compared with open resection for treating subependymal giant cell astrocytoma. J Neurosurg Pediatr. 2023 Nov 3;33(1):95-104. doi: 10.3171/2023.8.PEDS23370. PMID: 37922551.
16. Bebin EM, Peters JM, Porter BE, McPherson TO, O’Kelley S, Sahin M, Taub KS, Rajaraman R, Randle SC, McClintock WM, Koenig MK, Frost MD, Northrup HA, Werner K, Nolan DA, Wong M, Krefting JL, Biasini F, Peri K, Cutter G, Krueger DA; PREVeNT Study Group. Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial. Ann Neurol. 2023 Aug 28:10.1002/ana.26778. doi: 10.1002/ana.26778. Epub ahead of print. PMID: 37638552; PMCID: PMC10899525.
17. Guo D, Zhang B, Han L, Rensing NR, Wong M. Cerebral vascular and blood brain-barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex. Epilepsia. 2024 Feb;65(2):483-496. doi: 10.1111/epi.17848. Epub 2023 Dec 16. PMID: 38049961; PMCID: PMC10922951.
18. Farach LS, Richard MA, Wulsin AC, Bebin EM, Krueger DA, Sahin M, Porter BE, McPherson TO, Peters JM, O’Kelley S, Taub KS, Rajaraman R, Randle SC, McClintock WM, Koenig MK, Frost MD, Werner K, Nolan DA, Wong M, Cutter G, Northrup H, Au KS; PREVeNT Study Group. Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial. Pediatr Neurol. 2024 Oct;159:62-71. doi: 10.1016/j.pediatrneurol.2024.06.012. Epub 2024 Jul 4. PMID: 39142021.